Migraine: A Disorder of the Trigeminal Nerve
The trigeminal nerve gets its name from its three divisions, each having specific responsibilities. The first two divisions (I and II) are primarily responsible for reporting sensations back to the brain (called sensory nerves). The busiest is the third division (III), which provides sensations from everything below the cheekbone, including teeth, lips, gums, and the jaw joint.
During a migraine, the main center for sensation reception (called the sensory nucleus) has become hyper-sensitized and responds unfavorably to normal outside stimuli. Part of the response to the stimuli (commonly known as triggers) can be chemical secretions (primarily CGRP) that irritate and inflame arteries surrounding the brain (resulting in migraine pain) and within the sinuses (resulting in pain, stuffiness and discharge, or sinus headache).
The NTI device reduces trigeminal motor hyper-activity and the resulting noxious sensations back to the trigeminal nerve.
While touching the muscles of your temples, bite down on a wooden pencil with your back teeth as hard as you can. You'll feel the muscle bulge as it intensely contracts. Now compare to when biting on the pencil with your front teeth only. That's how the NTI device works.
In clinical trials reviewed by the FDA, 82% of medically diagnosed migraine sufferers had a 77% average reduction of migraine pain attacks within the first eight weeks of use.
For more background on the pathophysiology of migraine, visit: